The Culture and Free Thought Association operates in the Gaza Strip, with a primary focus on the central and southern governorates. It expands its interventions based on humanitarian needs in Gaza City, the Central Governorate, Khan Younis, the Khan Younis area, and displacement camps and sites throughout the governorates.

In 2025, the association restructured its field presence after most of its facilities were damaged during the war. It transitioned to a more flexible response model based on integrated programs and interventions, rather than relying solely on centers. This model enabled the association to reach children, youth, women, people with disabilities, the elderly, internally displaced persons, and the most vulnerable families affected by war, displacement, and famine.